857080-71-8Relevant academic research and scientific papers
3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding
Li, Wei,Hu, Yonghan,Li, Jianchang,Thomason, Jennifer R.,DeVincentis, Dianne,Du, Xuemei,Wu, Junjun,Hotchandani, Rajeev,Rush III, Thomas S.,Skotnicki, Jerauld S.,Tam, Steve,Chockalingam, Priya S.,Morris, Elisabeth A.,Levin, Jeremy I.
, p. 4546 - 4550 (2009)
Potent 3,4-disubstituted benzofuran P1′ MMP-13 inhibitors have been prepared. Selectivity over MMP-2 was achieved through a substituent at the C4 position of the benzofuran P1′ moiety of the molecule. By replacing a backbone benzene with a pyridine and va
Biaryl sulfonamides and methods for using same
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Page/Page column 66, (2010/02/12)
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
