857228-83-2Relevant academic research and scientific papers
PREPARATION OF ARMODAFINIL FORM I
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Page/Page column 7-8, (2010/03/02)
Preparation of armodafinil crystalline Form I. Also provided is armodafinil having about 30% or more by weight of particles with sizes greater than about 250 μm, and about 70% or less by weight of particles having sizes less than about 250 μm, wherein of
(2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists
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, (2008/06/13)
The present invention relates to new (2-alkyl-3-pyridyl) methylpiperazine derivatives of general formula I: wherein R1, R2 and Z are as defined in Claim 1. The invention also relates to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent, orally active PAF antagonists and, consequently, they are useful in the treatment of the diseases in which this substance is involved.
New benzhydrysulphinyl derivatives
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, (2008/06/13)
The invention provides the benzhydrylsulphinyl derivatives of the formula: where n is 1, 2 or 3 and R is C(=O)NHOH, C(=NH)NH2, C(=NH)NHOH, 2-Δ2 -imidazolinyl or NR1 R2 (where R1 is H or C1 -C3 -alkyl and R2 is H, C1 -C3 -alkyl, or CH2 CH2 OH, and R1 and R2 considered together can form, with the nitrogen atom to which they are bonded, a N-heterocyclic group of 5 to 7 ring members, which can be substituted and can contain a second hetero-atom such as O and N), and their addition salts. These products are useful in therapy for treating disturbances of the central nervous system.
