857232-66-7Relevant academic research and scientific papers
A new route to tricyclic 2-pyridone frameworks via formation of bicyclic N-alkenyl alkynylamides followed by gold-catalyzed cycloisomerization
Imase, Hidetomo,Tanaka, Ken
supporting information; experimental part, p. 1152 - 1153 (2010/03/25)
A cationic gold(I)/PPh3 complex catalyzes cycloisomerizations of bicyclic N-alkenyl alkynylamides leading to tricyclic 2-pyridone derivatives at room temperature in good yields. The bicyclic N-alkenyl alkynylamides are readily prepared starting from commercially available 2-substituted cycloalkanones.
2,5-diarylisothiazolone: Novel inhibitors of cytokine-induced cartilage destruction
Wright, Stephen W.,Petraitis, Joseph J.,Freimark, Bruce,Giannaras, John V.,Pratta, Michael A.,Sherk, Susan R.,Williams, Jean M.,Magolda, Ronald L.,Arner, Elizabeth C.
, p. 851 - 858 (2007/10/03)
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n
