857264-48-3Relevant academic research and scientific papers
Spirocyclic compounds, potent CCR1 antagonists
Hossain, Nafizal,Ivanova, Svetlana,Bergare, Jonas,Eriksson, Tomas
, p. 1883 - 1886 (2013)
Conformationally constrained spirocycles (17-23) and (31-36) were synthesised. In vitro data revealed that these compounds are CCR1 antagonists with sub-nanomolar potency. In a functional assay 22, 23 and 36 inhibited CCR1 mediated chemotaxis with an ICs
