857283-60-4 Usage
Uses
Used in Pharmaceutical Industry:
1-(4-Isocyanatophenyl)-1H-pyrrole is used as a key intermediate for the synthesis of various organic compounds, particularly in drug discovery and development. Its unique structure and functional group contribute to the creation of new pharmaceutical agents with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-Isocyanatophenyl)-1H-pyrrole serves as a building block for the development of novel compounds with pesticidal, herbicidal, or fungicidal properties. Its incorporation into these compounds can enhance their effectiveness in protecting crops and managing pests.
Used in Materials Science:
1-(4-Isocyanatophenyl)-1H-pyrrole is used as a monomer in the preparation of polymers and other advanced materials. Its isocyanate group allows for versatile chemical reactions, leading to the development of materials with improved properties such as strength, durability, and resistance to environmental factors.
Overall, 1-(4-Isocyanatophenyl)-1H-pyrrole is a valuable compound with a wide range of applications across different industries, making it an important asset in the development of new products and technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 857283-60-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,7,2,8 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 857283-60:
(8*8)+(7*5)+(6*7)+(5*2)+(4*8)+(3*3)+(2*6)+(1*0)=204
204 % 10 = 4
So 857283-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H8N2O/c14-9-12-10-3-5-11(6-4-10)13-7-1-2-8-13/h1-8H
857283-60-4Relevant academic research and scientific papers
1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors
Wu, Lixin,Lu, Meiqi,Yan, Zhihui,Tang, Xiaobin,Sun, Bo,Liu, Wei,Zhou, Honggang,Yang, Cheng
, p. 2416 - 2426 (2014/05/06)
A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 = 1.15 nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site.
