85745-91-1Relevant academic research and scientific papers
SYNTHESIS OF 2-(6'-CARBOXYHEXYL)CYCLOPENT-2-EN-1-ONE (PROSTAGLANDIN SYNTHON) BY CYCLIZATION OF 5-HYDROXYDODECANE-1,12-DIOIC ACID
Bobrova, N. I.,Pivnitskii, K. K.
, p. 259 - 261 (2007/10/02)
The oxidation of 2-(6'-carboxyhexyl)cyclopentanone by persulfuric acid leads to a mixture of 5-hydroxydodecane-1,12-dioic acid and the corresponding δ-lactone.Cyclodehydration of the latter with polyphosphoric acid gives 2-(6'-carboxyhexyl)cyclopent-2-en-1-one (prostaglandin synthon) with an overall yield of 41percent.
