857478-33-2

Upstream product

• 857478-30-9 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-isovaline 
• 962-39-0 L-Phenylalanine benzyl ester 

Downstream Products

• 857478-53-6 (2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid pentafluorophenyl ester 
• 857478-37-6 (2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 857478-39-8 (2S,5S,8S,11S,13aR)-5-Benzyl-11-[(R)-7-(tert-butyl-diphenyl-silanyloxy)-6-oxo-octyl]-8-ethyl-2,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone 
• 857478-35-4 (2R,4S)-1-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-butyrylamino]-3-phenyl-propionyl}-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 857478-50-3 (S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-butyrylamino]-3-phenyl-propionic acid 

Relevant academic research and scientific papers

Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases

(Chemical Equation Presented) The total synthesis of FR235222, a potent immunosuppressant with in vivo activities, has been achieved. The key steps include assembling its (2S,9R)-2-amino-9-hydroxy-8-oxodecanoic acid residue via an olefin cross-metathesis of a methyl (R)-lactate-derived homoallyl ketone with protected allyl amino acid and constructing its trans-(2R,4S)-4-methylproline unit from protected (R)-pyroglutamic acid in seven steps.