857495-84-2

Basic information

• Product Name: 2-(4-aminophenoxy)-N-(4-methoxyphenyl)acetamide
• Synonyms: 2-(4-aminophenoxy)-N-(4-methoxyphenyl)acetamide;2-(4-aminophenoxy)-N-(4-methoxyphenyl)ethanamide;SBB006813;ZINC08306614
• CAS NO: 857495-84-2
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.31
• Mol File: 857495-84-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 544.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.253±0.06 g/cm3(Predicted)
• PKA: 13.00±0.70(Predicted)
• CAS DataBase Reference: 2-(4-aminophenoxy)-N-(4-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-aminophenoxy)-N-(4-methoxyphenyl)acetamide(857495-84-2)
• EPA Substance Registry System: 2-(4-aminophenoxy)-N-(4-methoxyphenyl)acetamide(857495-84-2)

Safety Data

• Hazardous Substances Data: 857495-84-2(Hazardous Substances Data)

Usage

Class

Organic compound, acetamides

Structure

Phenyl structure with an amino group (-NH2) and a methoxy group (-OCH3) attached

Derivative

Aniline derivative

Pharmaceutical applications

Used in the development of new drugs and medicinal formulations

Potential for research

Has properties and structure that make it a candidate for further research in drug discovery and development.

Upstream product

• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 104-94-9 4-methoxy-aniline 
• 303795-97-3 N-(4-methoxyphenyl)-2-(4-nitrophenoxy)acetamide 

Downstream Products

• 936632-83-6 1-deoxy-1-(2-chloro-6-{4-[(4-methoxyphenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 
• 936632-72-3 1-deoxy-1-(6-{4-[(4-methoxyphenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide 

Relevant articles and documents

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

A new series of N6-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines (24-43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl)-methoxy]-phenyl chain at the N6 position of 5′-N-ethylcarboxamido-adenosine led us to the recognition of compound 24 as a full agonist displaying the highest efficacy of the series (EC50 hA2B = 7.3 nM). These compounds represent the first report about adenosine-related structures capable of activating hA2B subtype in the low nanomolar range.