857500-79-9Relevant academic research and scientific papers
Efficient synthesis of polysubstituted pyridine under solvent-free conditions without using any catalysts
Rong, Liangce,Han, Hongxia,Wang, Suhui,Zhuang, Qiya
, p. 1808 - 1814 (2008)
A convenient and environmentally friendly solvent-free procedure has been developed for the synthesis of polysubsituted pyridine derivatives. Compared with the classical reaction condition, this new synthetic method has the advantage of excellent yields,
An efficient approach towards the synthesis, crystal structures, DFT and cytotoxic activity of highly congested 11-aryl-10,12-dihydrodiindino[1,2-b′,2′,1′-e]pyridine
Asiri, Abdullah M.,Faidallah, Hassan M.,Al-Youbi, Abdulrahman O.,Arshad, Muhammed Nadeem,Osman, Osman I.,Zayed, Mohie E. M.
, p. 428 - 435 (2016)
An efficient and novel method for the synthesis of a series of 11-aryl-10,12-dihydrodiindino[1,2-b′,2′,1′-e]pyridine via one-pot multi-component reactions of aldehydes, indan-1-one and ammonium acetate has been delineated. All prepared compounds were structurally elucidated by IR, UV-Vis, 1H and 13C NMR and X-ray diffraction techniques. The molecules adopted monoclinic crystal system with P21/c space group and almost similar unit cell dimensions. The X-ray molecular geometries of the studied compounds were in excellent agreement with those computed by B3LYP/6-311++G(d,p) level of theory. The energies of the frontier orbitals calculated by B3LYP/6-311++G(d,p) level of theory enabled monitoring the reactivity and stability of the title molecules. The non-linear optical properties (NLO) and pNA were also computed and discussed. Compounds have shown broad spectrum cytotoxic activity against some human tumour cell lines; two of them rendering the most profound effect.
