857561-62-7

Upstream product

• 19853-09-9 2-phenylbenzyl bromide 
• 874-90-8 4-methoxybenzonitrile 
• 643-58-3 2-methylbiphenyl 
• 768-60-5 4-methoxyphenylacetylen 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 875819-51-5 2-biphenyl-2-yl-3-(4-methoxy-phenyl)-3-oxo-propionitrile 

Relevant academic research and scientific papers

Redox-Neutral Arylations of Vinyl Cation Intermediates

Herein we present a new unified concept for C?C bond formation under redox-neutral conditions. Our strategy hinges upon interception of a vinyl cation with a sulfoxide resulting in simultaneous C–C and C?O bond formation and arylation. A range of structurally diverse vinyl cations are generated in situ in the presence of a sulfoxide, resulting in hydrative arylation, direct arylation of enol triflates and interrupted Meyer–Schuster rearrangement. Mechanistic investigations showcase the crucial role played by the fleeting vinyl cation intermediate and structural features that lead to its stabilization. Applications of the reaction products to synthesis are also presented. (Figure presented.).

Br?nsted Acid-Mediated Hydrative Arylation of Unactivated Alkynes

The Br?nsted acid-mediated reaction of unactivated alkynes with aryl sulfoxides leads to simultaneous hydration and intermolecular C-C bond formation. This solvent- A nd metal-free transformation directly delivers α-arylated carbonyl compounds as the prod