857641-46-4

Basic information

• Product Name: 2-(4-BROMO-1H-PYRAZOL-1-YL)PYRIMIDINE
• Synonyms: 2-(4-BROMO-1H-PYRAZOL-1-YL)PYRIMIDINE;2-(4-bromopyrazol-1-yl)pyrimidine
• CAS NO: 857641-46-4
• Molecular Formula: C₇H₅BrN₄
• Molecular Weight: 225.05
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 857641-46-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 402.2°C at 760 mmHg
• Flash Point: 197°C
• Appearance: /
• Density: 1.79g/cm³
• Vapor Pressure: 1.12E-06mmHg at 25°C
• Refractive Index: 1.734
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.85±0.33(Predicted)
• CAS DataBase Reference: 2-(4-BROMO-1H-PYRAZOL-1-YL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMO-1H-PYRAZOL-1-YL)PYRIMIDINE(857641-46-4)
• EPA Substance Registry System: 2-(4-BROMO-1H-PYRAZOL-1-YL)PYRIMIDINE(857641-46-4)

Safety Data

• Hazardous Substances Data: 857641-46-4(Hazardous Substances Data)

Usage

General Description

The chemical compound 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine is a heterocyclic organic compound with the molecular formula C7H5BrN4. It consists of a pyridine ring fused to a pyrazole ring and a bromine atom attached to the pyrazole ring. 2-(4-BROMO-1H-PYRAZOL-1-YL)PYRIMIDINE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable intermediate in the production of various biologically active compounds. Additionally, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine has potential applications in medicinal chemistry and drug discovery due to its diverse properties and functional groups.

InChI:InChI=1/C7H5BrN4/c8-6-4-11-12(5-6)7-9-2-1-3-10-7/h1-5H

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 1722-12-9 2-chloropyrimidine 
• 82882-56-2 1-(pyrimidin-2-yl)-1H-pyrazole 

Downstream Products

• 857641-50-0 [Pd(η3-C4H7)(2-(4-bromo-1H-pyrazol-1-yl)pyrimidine)][tetrakis(3,5-trifluoromethylphenyl)borate] 
• 1312940-07-0 propane-1-sulfonic acid {2,4-difluoro-3-[5-(1-pyrimidin-2-yl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide 

Relevant articles and documents

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME parameters by means of lowering log D was identified, and this was achieved by replacement of a six-membered (hetero)aromatic linker with a pyrazole. A short SAR study has delivered key examples with useful in vitro activity and ADME profiles, good selectivity against a human kinase panel and improved levels of lipophilic ligand efficiency. These new analogues thus provide a credible additional route to further development of the series.

POLYCYCLIC INDAZOLE DERIVATIVES AND THEIR USE AS ERK INHIBITORS FOR THE TREATMENT OF CANCER

Disclosed are the ERK inhibitors of formula 1.0: (Chemical formula should be inserted here as it appears on abstract in paper form) and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.