857682-06-5Relevant academic research and scientific papers
Selective substituent transfer from mixed zinc reagents in Ni-catalyzed anhydride alkylation
Johnson, Jeffrey B.,Yu, Robert T.,Fink, Paul,Bercot, Eric A.,Rovis, Tomislav
, p. 4307 - 4310 (2006)
(Chemical Equation Presented) The use of mixed zinc reagents in Ni-catalyzed anhydride alkylation results in preferential transfer of substituents (Ph > Me > Et ? iPr ～ TMSCH2) for the ligands bipy, dppe, and iPrPHOX. Utilization of such mixed
Practical synthesis of chiral cis-cyclohex-4-ene-1,2-dicarboxylic acid derivatives by utilizing (4S)-isopropyl-1,3-thiazolidine-2-thione
Van Dang, Tinh,Miyamoto, Motoyuki,Sano, Shigeki,Shiro, Motoo,Nagao, Yoshimitsu
, p. 1139 - 1157 (2007/10/03)
Both enantiomers of chiral cis-cyclohex-4-ene-1,2-dicarboxylic acid derivatives were synthesized by optical resolution of the corresponding enantiomeric mixtures by utilizing (4S)-isopropyl-1,3-thiazolidine-2-thione followed by mild aminolysis, methanolys
A palladium-catalyzed enantioselective alkylative desymmetrization of meso-succinic anhydrides
Bercot, Eric A.,Rovis, Tomislav
, p. 10248 - 10249 (2007/10/03)
Monoalkylation of cyclic anhydrides provides an opportunity to couple a carbon-carbon bond-forming event with the control of backbone stereochemistry. We have developed a palladium-JOSIPHOS catalyst system that desymmetrizes meso-succinic anhydrides using organozinc reagents as nucleophiles, and have found that, in many cases, this reaction proceeds at ambient temperature. Copyright
