857684-36-7

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 4546-74-1 7H-3,6-dihydro-1,2,3-triazolo[4,5-d]pyrimidin-7-one 2'-deoxy-β-D-ribonucleoside 
• 127278-04-0 7-methoxy-3-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-3H-1,2,3-triazolo<4,5-d>pyrimidine 

Relevant academic research and scientific papers

CYCLIC DINUCLEOTIDES AS STING AGONISTS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1', X1, B1

Replacement of canonical DNA nucleobases by benzotriazole and 1,2,3-triazolo[4,5-d]pyrimidine: Synthesis, fluorescence, and ambiguous base pairing

The syntheses and the fluorescence properties of 7H-3,6-dihydro-1,2,3- triazolo[4,5-d]pyrimidin-7-one 2′-deoxy-β-D-ribonucleosides (=2′-deoxy-8-azainosine) 3 (N3), 15 (N2), and 16 (N1) as well as of 1,2,3-benzotriazole 2′-O-methyl-β- or -α-D-ribofuranosides 6 (N1) and 24 (N1) are described. Also the fluorescence properties of 1,2,3-benzotriazole 2′-deoxy-β-D-ribofuranosides 4 (N1) and 5 (N2) are evaluated. From the nucleosides 3-6, the phosphoramidites 19, 26a, 26b, and 28 are prepared and employed in solid-phase oligonucleotide synthesis. In 12-mer DNA duplexes, compound 3 shows similar ambiguous base-pairing properties as 2′-deoxyinosine (1), while the nucleosides 4-6 show strong pairing with each other and discriminate very little the four canonical DNA constituents.