857732-39-9Relevant academic research and scientific papers
Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate
Sturgess, Dayna,Chen, Zongjia,White, Jonathan M.,Rizzacasa, Mark A.
, p. 234 - 239 (2018/03/21)
The total syntheses of both the natural and unnatural enantiomers of the alkyl citrate natural product CJ-13,982 (1) from the common d-ribose-derived acid 6 are described.
Enantiospecific synthesis of the heparanase inhibitor (+)-trachyspic acid and stereoisomers from a common precursor
Zammit, Steven C.,Ferro, Vito,Hammond, Edward,Rizzacasa, Mark A.
, p. 2826 - 2834 (2008/03/14)
The total synthesis of natural (+)-trachyspic acid and its enantiomer is described starting from a common 2-deoxy-d-ribose derivative. The synthesis of the corresponding C3 epimers from the same starting material is also described. Each stereoisomer was a
Enantiospecific synthesis of (-)-trachyspic acid
Zammit, Steven C.,White, Jonathan M.,Rizzacasa, Mark A.
, p. 2073 - 2074 (2007/10/03)
The enantiospecific synthesis of (-)-trachyspic acid is presented. The D-oxyribose derived alcohol was oxidized in one step to the acid and esterification with allyl alcohol provided ester. Alkylation of the anion derived from dimethyl malonate with nonyl
