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Usage

Common Usage

As a nonsteroidal anti-inflammatory drug (NSAID)
Frequently used to treat conditions like arthritis, menstrual cramps, and mild to moderate pain.

Physical Form

White to off-white crystalline powder
The compound is often found in this form for pharmaceutical applications.

Mechanism of Action

Inhibition of prostaglandin production
It works by inhibiting the production of prostaglandins, which are chemicals responsible for inflammation, pain, and fever in the body.

Oral Administration

Typically taken orally
The compound is usually administered orally for its therapeutic effects.

Therapeutic Properties

Analgesic, anti-inflammatory, and antipyretic
It has pain-relieving, inflammation-reducing, and fever-reducing properties.

Potential Side Effects

Gastrointestinal irritation, renal toxicity, and increased risk of bleeding
Users may experience these side effects while taking the compound.

Upstream product

• 101518-61-0 2,2-dimethyl-3-phenylpropanamide 
• 636-98-6 p-nitrobenzene iodide 
• 75-98-9 Trimethylacetic acid 
• 1384980-40-8 methyl 2,2-dimethyl-3-(4-nitrophenyl)propanoate 
• 94800-92-7 ethyl 2,2-dimethyl-3-phenylpropionate 
• 25491-42-3 ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate 
• 5669-14-7 2,2-dimethyl-3-phenylpropanoic acid 

Downstream Products

• 1384980-67-9 N-[3-acetoxy-2-(4-nitrobenzyl)-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine 
• 1384980-48-6 N-[2,2-dimethyl-3-(4-nitrophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine 
• 854210-73-4 2-methyl-1-(4-nitro-phenyl)-2-phenyl-propane 
• 50818-24-1 2,2-dimethyl-3-(4-nitro-phenyl)-propionyl chloride 

Relevant academic research and scientific papers

Palladium-Catalyzed β-Arylation of Amide via Primary sp3C-H Activation

A β-arylation of primary sp3C-H bonds on simple amides such as pivalamides with aryl iodides/CF3CO2Ag has been established successfully at 120 °C in a Pd(OAc)2 (catalyst)/CF3CH2OH (solvent) system. Pivalamides including tBuCONH2, tBuCONHR, and tBuCONR2 undergo the arylations smoothly to afford β-aryl pivalamides in moderate to good yields. Various aryl iodides are available bearing either electron-donating or electron-withdrawing substituted groups in the coupling reactions.

Pd(II)-catalyzed primary-C(sp3)-H acyloxylation at room temperature

With the aid of a novel S-methyl-S-2-pyridyl-sulfoximine (MPyS) directing group (DG), the unactivated primary β-C(sp3)-H bond of MPyS-N-amides oxidizes at room temperature. The catalytic conditions are applicable to the diacetoxylation of primary β,β′-C(sp 3)-H bonds, and the carboxylic acid solvent is pivotal in the formation of the C-O bond. The MPyS-DG cleaves from the oxidation products and is recovered. This method provides convenient access to α,α′- disubstituted-β-hydroxycarboxylic acids.