857804-76-3

Upstream product

• 183489-05-6 1,3-Dioxo-2-p-tolyl-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid ethyl ester 
• 703-59-3 homophthalic anhydride 
• 106-49-0 p-toluidine 
• 73109-31-6 2-(4-methylphenyl)-1,3(2H,4H)-dioxoisoquinoline 
• 183489-22-7 4-Benzoyloxy-1,3-dioxo-2-p-tolyl-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Isoquinoline-1,3,4-trione derivative and preparation method thereof

The invention discloses an isoquinoline-1,3,4-trione derivative and a preparation method thereof. The method is characterized in that the isoquinoline-1,3,4-trione derivative is prepared through a reaction of a 3-amino-4-cyano-2-substituted isoquinoline-1-one derivative used as a substrate and an aqueous solution of tert-butyl hydroperoxide at 60-80 DEG C in an organic solvent with copper salt as a catalyst. The method can be used for obtaining multiple isoquinoline-1,3,4-trione derivatives at a high yield, and has the advantages of mild reaction conditions, simplicity in operation and post-treatment, and suitableness for large-scale production.