857858-99-2

Upstream product

• 591-50-4 iodobenzene 
• 220426-78-8 [but-3-enyl-((1R)-phenyl-ethyl)-amino]-acetic acid ethyl ester 
• 177944-16-0 (R)-N-(but-3-en-1-yl)-N-(α-methylbenzyl)amine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 312625-23-3 (3S,4S)-4-benzyl-1-[2-(4-hydroxybenzenesulfonyl)ethyl]piperidin-3-ol 
• 857859-01-9 (3S,4S)-4-Benzyl-1-((R)-1-phenyl-ethyl)-piperidin-3-ol 
• 312625-28-8 (3S,4S)-4-benzylpiperidin-3-ol 
• 857859-00-8 [(2R,3S)-3-Benzyl-1-((R)-1-phenyl-ethyl)-pyrrolidin-2-yl]-methanol 

Relevant academic research and scientific papers

Efficient enantioselective formal synthesis of Ro 67-8867, a NMDA 2B receptor antagonist

An efficient enantioselective formal synthesis of Ro 67-8867 has been achieved in 7 steps using an amino-zinc-ene-enolate cyclization and an enantioselective ring enlargement of a substituted prolinol as the key steps.