85788-75-6

Basic information

• Product Name: 2-amino-5-(3'-hydroxyphenyl)-1,3,4-oxadiazole
• Synonyms: 2-amino-5-(3'-hydroxyphenyl)-1,3,4-oxadiazole
• CAS NO: 85788-75-6
• Molecular Weight: 177.162
• Mol File: 85788-75-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-amino-5-(3'-hydroxyphenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-(3'-hydroxyphenyl)-1,3,4-oxadiazole(85788-75-6)
• EPA Substance Registry System: 2-amino-5-(3'-hydroxyphenyl)-1,3,4-oxadiazole(85788-75-6)

Safety Data

• Hazardous Substances Data: 85788-75-6(Hazardous Substances Data)

Usage

Potential applications

pharmaceutical and material science industries

Structure

heterocyclic molecule containing nitrogen and oxygen atoms

Use

drug design and development

Investigated for

potential as a fluorescent probe for detecting metal ions

Potential as

chelating agent for coordinating with metal ions in biological and environmental systems

Valuable building block for

synthesis of novel materials with potential applications in various industries
Versatile and potentially valuable chemical compound with a range of potential uses in different fields

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 120445-49-0 2-(3'-hydroxyphenyl)methylene semicarbazide 
• 506-68-3 bromocyane 
• 5818-06-4 3-hydroxybenzoic hydrazide 

Downstream Products

• 23104-05-4 2-(3-hydroxy-phenyl)-7-methyl-[1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one 
• 28004-17-3 2-(3-hydroxy-phenyl)-5-oxo-5H-[1,3,4]oxadiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 1421633-75-1 C₉H₉N₅O₃ 
• 1421633-64-8 C₉H₈N₄O₃ 

Relevant articles and documents

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking studies of 2-amino-1,3,4-oxadiazole derivatives

Background: In the recent past, we have synthesized and reported different derivatives of oxadiazoles as potential α-glucosidase inhibitors, keeping in mind, the pharmacological aspects of oxadiazole moiety and in continuation of our ongoing research on the chemistry and bioactivity of new heterocyclic compounds. Methods: 1,3,4-Oxadiazole derivatives (1-14) have been synthesized and characterized by different spectroscopic techniques such as1 H-,13 C-NMR and HREI-MS. Results: The synthetic derivatives were screened for α-glucosidase inhibitory potential. All compounds exhibited good inhibitory activity with IC50 values ranging between 0.80 ± 0.1 to 45.1 ± 1.7 μM in comparison with the standard acarbose having IC50 value 38.45 ± 0.80 μM. Conclusion: Thirteen compounds 1-6 and 8-14 showed potential inhibitory activity as compared to the standard acarbose having IC50 value 38.45 ± 0.80 μM, however, only one compound 7 (IC50 = 45.1 ± 1.7 μM) was found to be less active. Compound 14 (IC50 = 0.80 ± 0.1 μM) showed promising inhibitory activity among all synthetic derivatives. Molecular docking studies were also conducted for the active compounds to understand the ligand-enzyme binding interactions.

A 2-amino-5-substituted -1, 3, 4-oxadiazoles and its preparation method and application

The invention relates to 2-amido-5-substituted-1,3,4-oxadiazole as well as a preparation method and application thereof. The preparation method comprises the following steps: adding semicarbazone, manganese dioxide and pyridine into a reaction vessel, rea