857893-07-3Relevant academic research and scientific papers
Syntheses of novel indole lipoic acid derivatives and their antioxidant effects on lipid peroxidation
Gurkan, A. Selen,Karabay, Arzu,Buyukbingol, Zeliha,Adejare, Adeboye,Buyukbingol, Erdem
, p. 67 - 73 (2005)
The aim of the study was to examine antioxidant properties of conjugates based on indole and lipoic acid moieties. The design and syntheses of novel indole α-lipoic acid derivatives were performed. The antioxidant properties of target compounds were investigated using rat liver microsomal, NADPH-dependent lipid peroxidation inhibition. Some of the target compounds, especially those containing amide linker at position 5 of indole ring, proved to be highly effective in inhibiting lipid peroxidation as compared to α-lipoic acid.
