85803-62-9

Usage

Uses

Used in Organic Synthesis:
2-(4-Methylpiperazino)benzaldehyde is used as an intermediate in the synthesis of complex organic compounds. Its unique structure allows for the creation of a variety of molecules that can be utilized in different applications across various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(4-Methylpiperazino)benzaldehyde is used as a building block for the development of new drugs. Its chemical structure can be modified to create potential therapeutic agents that can be tested for their efficacy and safety in treating various medical conditions.
Used in Chemical Research:
2-(4-Methylpiperazino)benzaldehyde is also used in chemical research as a model compound to study the properties and reactions of similar organic compounds. This can lead to a better understanding of the underlying chemical principles and contribute to the advancement of the field.
Used in Material Science:
In the field of material science, 2-(4-Methylpiperazino)benzaldehyde may be used to develop new materials with specific properties. Its incorporation into polymers or other materials can result in novel materials with unique characteristics, such as improved stability, enhanced reactivity, or altered physical properties.

InChI:InChI=1/C12H16N2O/c1-13-6-8-14(9-7-13)12-5-3-2-4-11(12)10-15/h2-5,10H,6-9H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 247157-96-6 1-methyl-4-[2-(2-nitrovinyl)phenyl]piperazine 
• 655256-68-1 (2-(4-methylpiperazin-1-yl)phenyl)methanamine 
• 1095224-50-2 N-methyl-2-(4-methylpiperazin-1-yl)benzylamine 
• 112253-36-8 2-[2-(4-Methyl-piperazin-1-yl)-benzylidene]-malononitrile 
• 1344706-49-5 1-(1-methyl-1H-indol-3-yl)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-prop-2-en-1-one 
• 886593-59-5 [2-(4-methylpiperazin-1-yl)phenyl]acetaldehyde 

Relevant academic research and scientific papers

Ruthenium catalyzed β-C(sp3)-H functionalization on the 'privileged' piperazine nucleus

β-C(sp3)-H functionalization on the 'privileged' piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade.

Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids

A new series of spiro-quinoline compounds have been accomplished by the reaction of barbituric acid or thiobarbituric acid with derivatives of benzisoxazole-5-carbaldehyde or 2-substituted benzaldehyde. These compounds were evaluated for their in vitro cy

PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR

The present invention relates to novel derivatives, that are compounds of Formula (I), wherein R1, R2, R3, R14, X, Y, n and m are defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and methods using said compounds in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, antagonists of 5-HT1B are useful.

Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents

It has been reported that 2-hydroxycinnamaldehyde and 2-benzoyl- oxycinnamaldehyde inhibited the activity of farnesyl protein transferase, angiogenesis, cell-cell adhesion, and tumor growth in vivo model. In order to improve its anti-tumor activity, dimer

NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES

The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula (I) wherein R1 is a group of the formula G1 or G2 depicted below, wherein R1, R3, R6, R13, X, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1B receptors. The compounds of the invention are useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated and have reduced potential for cardiac side effects, in particular QTc prolongation.

ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES

The present invention relates to compounds of the formula (I) wherein R1, R2, R3, X, Y and the dashed line are defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use as psychotherapeutic agents.

tert-Amino effect in heterocyclic chemistry. Synthesis of hydrogenated spiro derivatives of quinolines

A new method was developed for the one-step synthesis of spiro derivatives of fused quinolines by the reactions of ortho-amino derivatives of benzaldehyde with Meldrum's acid, cyclohexane-1,3-dione, or N,N′-disubstituted barbituric acids.

Cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, preparations and pharmaceutical compositions thereof

The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be ef

Process for the preparation of 2-(4-alkyl-1-piperazinyl)-benzaldehyde and -benzylidenyl compounds

The present invention relates to a novel process for the preparation of a compound of formula I: 1wherein R1 is defined herein and compounds of formula II: 2wherein R1 and R2 are defined herein. Said compound of formula

A Novel Two-Step Synthesis of Hexahydropyrazinoquinolines

The hexahydropyrazinoquinolines 2 were prepared in good yields by reaction of 2-(4-substituted 1-piperazinyl)benzaldehydes 5 with malononitrile and subsequent thermal cyclization of the condensation products 6; the latter reaction takes place via a