85803-62-9Relevant articles and documents
Ruthenium catalyzed β-C(sp3)-H functionalization on the 'privileged' piperazine nucleus
Murugesh,Bruneau, Christian,Achard, Mathieu,Sahoo, Apurba Ranjan,Sharma, Gangavaram V. M.,Suresh, Surisetti
supporting information, p. 10448 - 10451 (2017/09/25)
β-C(sp3)-H functionalization on the 'privileged' piperazine nucleus has been disclosed using ruthenium catalysis. The ruthenium catalyzed synthesis of a variety of piperazine fused indoles from ortho-piperazinyl (hetero)aryl aldehydes is presented. This transformation takes place via the dehydrogenation of piperazine followed by an intramolecular nucleophilic addition of the transient enamine moiety onto the carbonyl group and aromatization cascade.
PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR
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Page/Page column 83, (2010/11/30)
The present invention relates to novel derivatives, that are compounds of Formula (I), wherein R1, R2, R3, R14, X, Y, n and m are defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and methods using said compounds in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, antagonists of 5-HT1B are useful.
ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES
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Page/Page column 50, (2008/06/13)
The present invention relates to compounds of the formula (I) wherein R1, R2, R3, X, Y and the dashed line are defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use as psychotherapeutic agents.