85806-17-3 Usage
Uses
Used in Research and Development:
N-TriMethyl-γ-aMinobutyric Acid-d9 Chloride is used as a transporter substrate for the cloning and sequencing of human carnitine transporter 2 (CT2). This application is crucial in understanding the mechanisms and functions of carnitine transporters, which play a significant role in various biological processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-TriMethyl-γ-aMinobutyric Acid-d9 Chloride is used as a reference compound for the development and optimization of drugs targeting carnitine transporters. Its stable isotope labeling allows for accurate tracking and quantification of the compound in biological systems, facilitating the study of drug interactions and efficacy.
Used in Analytical Chemistry:
N-TriMethyl-γ-aMinobutyric Acid-d9 Chloride is employed as an internal standard in analytical chemistry, particularly in mass spectrometry and chromatographic techniques. The presence of deuterium atoms in the compound provides a distinct mass signature, enabling accurate quantification and identification of related compounds in complex samples.
Used in Neurobiology Research:
As a labeled analogue of γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the central nervous system, N-TriMethyl-γ-aMinobutyric Acid-d9 Chloride is utilized in neurobiological research to study the synthesis, transport, and function of GABA in the brain. This helps in understanding the role of GABA in various neurological disorders and the development of potential therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 85806-17-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,8,0 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 85806-17:
(7*8)+(6*5)+(5*8)+(4*0)+(3*6)+(2*1)+(1*7)=153
153 % 10 = 3
So 85806-17-3 is a valid CAS Registry Number.
85806-17-3Relevant academic research and scientific papers
Morano, Cain,Zhang, Xin,Fricker, Lloyd D.
, p. 9298 - 9309 (2008)
Quantitative mass spectrometry is often performed using isotopicalty labeled samples. Although the 4-trimethylammoniumbutyryl (TMAB) labels have many advantages over other isotopic tags, only two forms have previously been synthesized (i.e., a heavy form containing nine deuteriums and a light form without deuterium). In the present report, two additional forms containing three and six deuteriums have been synthesized and tested. These additional isotopic tags perform identically to the previously reported tags; peptides labeled with the new TMAB reagents coelute from reversed-phase HPLC columns with peptides labeled with the lighter and heavier TMAB reagents. Altogether, these four tags allow for multivariate analysis in a single liquid chromatography/mass spectrometry analysis, with each isotopically tagged peptide differing in mass by 3 Da per tag incorporated. The synthetic scheme is described in simple terms so that a biochemist without specific training in organic chemistry can perform the synthesis. The interpretation of tandem mass spectrometry data for the TMAB-labeled peptides is also described in more detail. The additional TMAB isotopic reagents described here, together with the additional description of the synthesis and analysis, should allow these labels to be more widely used for proteomics and peptidomics analyses.
