85811-56-9 Usage
Uses
Used in Pharmaceutical Industry:
7-CHLOROMETHYL-3-PHENYL-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE is used as a novel PKM2 activator for its potential role in cancer therapy. Pyruvate kinase M2 (PKM2) is an enzyme that plays a crucial role in the Warburg effect, which is a metabolic characteristic of cancer cells. By activating PKM2, 7-CHLOROMETHYL-3-PHENYL-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE may help in modulating the metabolic pathways in cancer cells, leading to the inhibition of tumor growth and progression.
Additionally, 7-CHLOROMETHYL-3-PHENYL-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE can be further explored for its potential applications in other therapeutic areas, such as diabetes, neurodegenerative diseases, and inflammatory conditions, where PKM2 activation may provide beneficial effects.
Used in Chemical Research:
7-CHLOROMETHYL-3-PHENYL-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE can also be utilized as a starting material or intermediate in the synthesis of other related compounds with potential applications in various fields. Its unique structural features and reactivity make it a valuable tool for the development of new drugs, agrochemicals, or materials with improved properties.
Check Digit Verification of cas no
The CAS Registry Mumber 85811-56-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,8,1 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 85811-56:
(7*8)+(6*5)+(5*8)+(4*1)+(3*1)+(2*5)+(1*6)=149
149 % 10 = 9
So 85811-56-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H9ClN2OS/c14-7-10-6-12(17)16-11(8-18-13(16)15-10)9-4-2-1-3-5-9/h1-6,8H,7H2
85811-56-9Relevant academic research and scientific papers
Chloromethyl Substituted Heterocycles from Methyl Chlorotetrolate
Janietz, D.,Goldmann, B.,Rudorf, W.-D.
, p. 607 - 616 (2007/10/02)
Reaction of amidines, isothioureas or thioureas with methyl chlorotetrolate 1 leads to pyrimidin-4-ones 2 and 1,3-thiazines (3), respectively.Compounds 2 and 3 are starting materials for the synthesis of 6-chloromethyl-uracils (4), 1,3-thiazine-2,4-dione 5 and 6-benzylthiomethyl-thiazinone (6). 2-Aminothiazoles react with the ester 1 to yield 5-chloromethyl-thiazolopyrimidin-7-ones (7).The 5-oxo isomers 8 are obtained by reaction of thiazoles with ethyl γ-chloroacetoacetate.By reaction of 2-mercaptoimidazoles and 1 or chlorotetrolic acid the condensed 1,3-thiazinones (10) result.In the latter case the intermediate 9 is isolated.It can be cyclised to 10 by heating with acetic anhydride and sulphuric acid.
