858125-74-3Relevant academic research and scientific papers
Phosphine-Catalyzed Cascade Annulation of MBH Carbonates and Diazenes: Synthesis of Hexahydrocyclopenta[c]pyrazole Derivatives
Guo, Hongchao,Li, Hongxiang,Liu, Hao,Shi, Wangyu,Wang, Chang,Wang, Wei,Wu, Yongjun
, p. 5571 - 5575 (2021)
A phosphine-catalyzed cascade annulation of Morita-Baylis-Hillman (MBH) carbonates and diazenes was achieved, giving tetrahydropyrazole-fused heterocycles bearing two five-membered rings in moderate to excellent yields. The reaction underwent an unprecedented reaction mode of MBH carbonates, in which two molecules of MBH carbonates were fully merged into the ring system.
Convenient general asymmetric synthesis of roche ester derivatives through catalytic asymmetric hydrogenation: Steric and electronic effects of ligands
Pautigny, Cyrielle,Jeulin, Severine,Ayad, Tahar,Zhang, Zhaoguo,Genet, Jean-Pierre,Ratovelomanana-Vidal, Virginie
supporting information; experimental part, p. 2525 - 2532 (2009/09/07)
An efficient and concise asymmetric hydrogenation of acrylate esters promoted by the cationic ruthenium monohydride complex [Ru(H) (hη6-cot)SYNPHOS]+BF44- is reported. A full investigation of the effects of catalyst precursors, solvents, temperature, hydrogen pressure, substrates as well as steric and electronic properties of ligands was carried out. The corresponding valuable Roche ester derivatives were obtained in good to excellent isolated yields and high enantioselectivities under mild conditions. The robustness and practicability of this highly enantioselective hydrogenation was demonstrated by the synthesis of the 3-hydroxy-2-methylpropanoic acid tert-butyl ester on a multigram scale, resulting in excellent yield and ee up to 94%.
Process for producing hydroxyl group-containing vinyl compound
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Page/Page column 7; 8; 9, (2008/06/13)
A process for producing a hydroxyl group-containing vinyl compound, the process comprising: reacting an acrylate compound and an aldehyde-based compound in a presence of a tertiary amine compound and water in a reaction solution to produce a hydroxyl group-containing vinyl compound, wherein the reaction is performed by adding an inorganic salt of a Group 1 or 2 metal of Periodic Table to the reaction solution.
