858126-76-8 Usage
Uses
Used in Bioconjugation:
DNP-PEG4-acid is used as a bioconjugation agent for attaching biomolecules to various surfaces or other molecules. The carboxylic acid group enables the formation of stable amide bonds with primary amines, which is crucial for the covalent attachment of proteins, peptides, or other amine-containing molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, DNP-PEG4-acid is utilized as a component in drug delivery systems. The PEG linker enhances the solubility and stability of drug molecules in aqueous solutions, which can improve their pharmacokinetics and biodistribution. Additionally, the DNP group may contribute to the transport of drugs across biological barriers.
Used in Membrane Transport Applications:
DNP-PEG4-acid is used as a component in systems designed to study or facilitate ion transport across membranes. The DNP group's known involvement in ion transport makes it a potentially useful part of constructs aimed at understanding or manipulating membrane permeability.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, DNP-PEG4-acid may be employed to improve the delivery and targeting of imaging agents. The PEGylation can enhance the solubility and circulation time of imaging probes, while the DNP group could potentially aid in their interaction with cellular targets.
Used in Biosensor Development:
DNP-PEG4-acid is used as a component in the development of biosensors. The ability to form stable amide bonds with biomolecules allows for the attachment of recognition elements, such as enzymes or antibodies, to sensor platforms. The DNP group may also contribute to signal transduction processes within the sensor.
Used in Theranostics:
In the emerging field of theranostics, which combines therapeutic and diagnostic applications, DNP-PEG4-acid could be employed to develop agents that both treat diseases and report on their status. The PEG linker would enhance the solubility and biocompatibility of these agents, while the DNP group could play a role in their therapeutic effect or diagnostic signal.
Check Digit Verification of cas no
The CAS Registry Mumber 858126-76-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,8,1,2 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 858126-76:
(8*8)+(7*5)+(6*8)+(5*1)+(4*2)+(3*6)+(2*7)+(1*6)=198
198 % 10 = 8
So 858126-76-8 is a valid CAS Registry Number.
858126-76-8Relevant academic research and scientific papers
Lefever, Mark,Kosmeder, Jerome W.,Farrell, Michael,Bieniarz, Christopher
, p. 1773 - 1778 (2010)
A novel method of linking haptens to deoxycytidine 5′-triphosphate via microwave-mediated bisulfate-catalyzed transamination with hydrazine has been developed. This method enables the tethering of small molecule haptens to dCTP via a discrete polyethylene
Microwave mediated synthesis of nucleic acid probes
-
, (2008/06/13)
A method for preparing a nucleic acid probe is provided. The method comprises forming an activated cytosine or cytidine by a bisulfite catalyzed reaction; and covalently linking a reporter molecule to the activated cytosine or cytidine, wherein said activating step, said covalently linking step, or both are conducted in the presence of microwave energy. Also provided by the invention are nucleic acid probes.
