858236-14-3

Basic information

• Product Name: 4-chloro-3-Methyl-1h-indole
• Synonyms: 4-chloro-3-Methyl-1h-indole;1H-INDOLE, 4-CHLORO-3-METHYL-
• CAS NO: 858236-14-3
• Molecular Formula: C9H8ClN
• Molecular Weight: 165.61952
• Mol File: 858236-14-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-3-Methyl-1h-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-3-Methyl-1h-indole(858236-14-3)
• EPA Substance Registry System: 4-chloro-3-Methyl-1h-indole(858236-14-3)

Safety Data

• Hazardous Substances Data: 858236-14-3(Hazardous Substances Data)

Upstream product

• 876-72-2 4-chloroindole-3-carboxaldehyde 
• 2519-61-1 4-chloroindole-3-acetic acid 

Downstream Products

• 1146972-37-3 N'-[3-(4-chloro-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine 

Relevant articles and documents

Organocatalytic Formal (3 + 2) Cycloaddition toward Chiral Pyrrolo[1,2- a]indoles via Dynamic Kinetic Resolution of Allene Intermediates

We report the chiral phosphoric acid catalyzed formal (3 + 2) cycloaddition of 3-substituted 1H-indoles and propargylic alcohols containing a functional directing group (p-NHAc or p-OH). This work represents a straightforward method to synthesize chiral pyrrolo[1,2-a]indole bearing a tetrasubstituted carbon stereocenter. The reaction proceeds smoothly with a wide array of substrate tolerance to deliver various chiral pyrrolo[1,2-a]indoles in up to 93percent yield and 98percent ee. The utility of this method is highlighted by the diverse transformations of the products into various indole derivatives.