858351-87-8Relevant academic research and scientific papers
Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy
Stanetty, Peter,Hattinger, Gregor,Schnuerch, Michael,Mihovilovic, Marko D.
, p. 5215 - 5220 (2005)
A novel, short, and efficient synthetic pathway to 3-{4-[2-(3- chlorophenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propanol (CGP 60474) and a series of analogues was developed. The synthetic sequence consisted of a Negishi-type cross-coupling reaction i
