858362-83-1 Usage
Uses
Used in Pharmaceutical Industry:
4-(aminomethyl)picolinonitrile is used as a key intermediate in the synthesis of various drugs, particularly antibiotics, due to its antimicrobial properties and effectiveness against a broad spectrum of bacteria. Its unique structure and reactivity make it an essential component in the development of new pharmaceuticals by medicinal chemists.
Used in Antibiotic Production:
4-(aminomethyl)picolinonitrile is used as a crucial ingredient in the production of antibiotics, which are essential for treating bacterial infections. Its antimicrobial properties allow it to target and eliminate a variety of bacteria, making it a valuable component in the development of effective medications for combating bacterial diseases.
Used in Medicinal Chemistry Research:
4-(aminomethyl)picolinonitrile is utilized as a versatile building block in medicinal chemistry research, where it serves as a starting material for the synthesis of new pharmaceuticals. Its unique structure and reactivity enable chemists to explore novel drug candidates with potential therapeutic applications, contributing to the advancement of the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 858362-83-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,8,3,6 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 858362-83:
(8*8)+(7*5)+(6*8)+(5*3)+(4*6)+(3*2)+(2*8)+(1*3)=211
211 % 10 = 1
So 858362-83-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H7N3/c8-4-6-1-2-10-7(3-6)5-9/h1-3H,4,8H2
858362-83-1Relevant academic research and scientific papers
Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: A potent and orally bioavailable NCX inhibitor
Kuramochi, Takahiro,Kakefuda, Akio,Yamada, Hiroyoshi,Tsukamoto, Issei,Taguchi, Taku,Sakamoto, Shuichi
, p. 4022 - 4036 (2007/10/03)
Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca 2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives, based on compound 5. We have discovered a novel NCX inhibitor (23h) with an IC 50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of compound 23h are discussed.
