858367-01-8

Upstream product

• 616-34-2 methoxycarbonylmethylamine 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 1040185-16-7 (2R,3S,4S,5S)-methyl 5-cyclohexyl-3,4-bis(phenylsulfonyl)pyrrolidine-2-carboxylate 
• 1006726-33-5 methyl 5-cyclohexyl-1H-pyrrole-2-carboxylate 
• 868526-19-6 {[(2S,3R,4S,5S)-3-((1S,2S)-1-Benzyloxy-2-methyl-butyl)-5-cyclohexyl-4-nitro-pyrrolidine-2-carbonyl]-amino}-acetic acid methyl ester 
• 858367-08-5 (2S,3R,4S,5S)-3-[(1S,2S)-1-(benzyloxy)-2-methylbutyl]-5-cyclohexyl-4-nitropyrrolidine-2-carboxylic acid 
• 858367-19-8 (2S,3R,4S,5S)-3-((1S,2S)-1-Benzyloxy-2-methyl-butyl)-5-cyclohexyl-4-nitro-pyrrolidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

CuI-Fesulphos complexes: efficient chiral catalysts for asymmetric 1,3-dipolar cycloaddition of azomethine ylides

The CuI-Fesulphos catalyst system (≤3 mol %) shows an excellent performance in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides. High to very high levels of reactivity, endo/exo selectivity, and enantioselectivity (69->99% ee) are generally achieved with a very wide range of azomethine ylides and dipolarophiles. Based on experimental and computational studies data, a model that accounts for this high enantiocontrol is proposed.

Oligopyrrole synthesis by 1,3-dipolar cycloaddition of azomethine ylides with bissulfonyl ethylenes

(Chemical Equation Presented) One by one or two by two: In a general approach to the iterative construction of oligopyrroles, the cycloaddition of azomethine ylides derived from pyrrolyl α-iminoesters with 1,2-bis(phenylsulfonyl)-ethylene is followed by the elimination of the sulfonyl groups in situ under basic conditions. This strategy is amenable to the introduction of one or two pyrrole units in each iterative cycle.