858445-49-5

Basic information

• Product Name: 1,1-bis(4-bromophenyl)-3-phenylprop-2-yn-1-ol
• Synonyms: 1,1-bis(4-bromophenyl)-3-phenylprop-2-yn-1-ol
• CAS NO: 858445-49-5
• Molecular Weight: 442.15
• Mol File: 858445-49-5.mol

Chemical Properties

• CAS DataBase Reference: 1,1-bis(4-bromophenyl)-3-phenylprop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis(4-bromophenyl)-3-phenylprop-2-yn-1-ol(858445-49-5)
• EPA Substance Registry System: 1,1-bis(4-bromophenyl)-3-phenylprop-2-yn-1-ol(858445-49-5)

Safety Data

• Hazardous Substances Data: 858445-49-5(Hazardous Substances Data)

Upstream product

• 6738-06-3 phenylethynylmagnesium bromide 
• 3988-03-2 bis(4-bromophenyl)methanone 
• 536-74-3 phenylacetylene 

Downstream Products

• 1192167-52-4 1,1-bis(4-bromophenyl)-5,7-dimethyl-3-phenyl-1H-inden-6-ol 
• 1242072-90-7 4-(bis(4-bromophenyl)methyl)-2-methyl-5-phenylthiazole 

Relevant articles and documents

Bronsted acid catalyzed cyclization of propargylic alcohols with thioamides. Facile synthesis of Di- and trisubstituted thiazoles

Figure presented. A general and efficient method to prepare 2,4-di- and trisubstituted thiazoles via p-TsOH·H2O-catalyzed cyclization of trisubstituted propargylic alcohols with thioamides is described. The reaction was accomplished in moderate to excellent product yields under mild conditions that did not require the exclusion of air and moisture and offers an operationally simplistic and convenient route to this synthetically useful aromatic heterocycle.

Ytterbium(III) triflate catalyzed tandem friedel-crafts alkylation/hydroarylation of propargylic alcohols with phenols as an expedient route to indenols

A method to prepare indenols efficiently by ytterbium(III) triflate catalyzed tandem Friedel - Crafts alkylation/hydroarylation of propargylic alcohols with phenols is described. The reaction was accomplished In moderate to excellent yields and regioselectivity under mild conditions and offers a straightforward and convenient one step synthetic route to bioactive indenols and its derivatives.