85853-22-1

Basic information

• Product Name: (16alpha,17beta)-16-(~123~I)iodoestra-1,3,5(10)-triene-3,17-diol
• CAS NO: 85853-22-1
• Molecular Formula: C₁₈H₂₃¹²³IO₂
• Molecular Weight: 394.374
• Mol File: 85853-22-1.mol
• Article Data: 1

Chemical Properties

• Density: 1.6g/cm³
• Refractive Index: 1.665
• CAS DataBase Reference: (16alpha,17beta)-16-(~123~I)iodoestra-1,3,5(10)-triene-3,17-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (16alpha,17beta)-16-(~123~I)iodoestra-1,3,5(10)-triene-3,17-diol(85853-22-1)
• EPA Substance Registry System: (16alpha,17beta)-16-(~123~I)iodoestra-1,3,5(10)-triene-3,17-diol(85853-22-1)

Safety Data

• Hazardous Substances Data: 85853-22-1(Hazardous Substances Data)

Upstream product

• 51946-42-0 16beta-Bromo-17beta-estradiol 

Relevant articles and documents

Process for the preparation of radioactive labeled estradiol

A method for producing a high yield of an estradiol labeled at the 16-alpha position thereof with a radioactive iodine, especially 123I, for use as an imaging agent. The method includes the step of mixing a source of 123I sodium iodine with 16-beta-bromoestradiol-17-beta and benzo-15-crown-5-ether in a water and organic solvent solution and heating under controlled temperature in the range from 90 to 120° Centigrade for sufficient time to react the iodide with the estradiol. Thereafter, resulting 16-alpha-123I iodoestradiol-17-beta is separated from the resultant mixture using high pressure liquid chromatography and then sterilized.