85858-94-2

Basic information

• Product Name: 1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE
• Synonyms: 1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE;1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE HCL;Methanone, (4-hydroxyphenyl)(4-methyl-1-piperazinyl)-;4-[(4-methylpiperazin-1-yl)carbonyl]phenol hydrochloride
• CAS NO: 85858-94-2
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 256.73
• Product Categories: Piperidines, Piperidones, Piperazines
• Mol File: 85858-94-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 401.9 °C at 760 mmHg
• Flash Point: 196.9 °C
• Appearance: /
• Density: 1.197 g/cm³
• Vapor Pressure: 4.91E-07mmHg at 25°C
• Refractive Index: 1.586
• PKA: 9.05±0.15(Predicted)
• CAS DataBase Reference: 1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE(85858-94-2)
• EPA Substance Registry System: 1-(4-HYDROXYBENZOYL)-4-METHYL-PIPERAZINE(85858-94-2)

Safety Data

• Hazardous Substances Data: 85858-94-2(Hazardous Substances Data)

Usage

General Description

1-(4-Hydroxybenzoyl)-4-methyl-piperazine is a chemical compound composed of a piperazine ring with a 4-hydroxybenzoyl group and a 4-methyl group. It is often used in pharmaceutical research as a potential drug candidate, as it has demonstrated biological activity in various studies. The 4-hydroxybenzoyl group is known for its antioxidant and anti-inflammatory properties, while the piperazine ring is a common structural motif in many pharmaceuticals and has been shown to have diverse pharmacological activities. The 4-methyl group may contribute to the compound's overall stability and biological activity. Further research is necessary to fully understand the potential uses and effects of 1-(4-Hydroxybenzoyl)-4-methyl-piperazine.

InChI:InChI=1/C12H16N2O2/c1-13-6-8-14(9-7-13)12(16)10-2-4-11(15)5-3-10/h2-5,15H,6-9H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 99-96-7 4-hydroxy-benzoic acid 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 157341-41-8 L-694,458 
• 346699-90-9 Acetic acid 4-(4-methyl-piperazine-1-carbonyl)-phenyl ester 

Downstream Products

• 548765-89-5 methyl-phenyl-carbamic acid 4-(4-methyl-piperazine-1-carbonyl)-phenyl ester 
• 157341-41-8 L-694,458 
• 181481-54-9 (4S)-3,3-diethyl-4-{4-[(4-methylpiperazinyl)-carbonyl]phenoxy}azetidin-2-one 
• 204855-17-4 3,3-diethyl-4-{4-[(4-methylpiperazin-1-yl)carbonyl]phenoxy}azetidin-2-one 
• 1235034-24-8 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(4-methylpiperazine-1-carbonyl)phenoxy)propyl)picolinic acid 

Relevant articles and documents

Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors

Serine/threonine protein kinases Aurora A, B, and C play essential roles in cell mitosis and cytokinesis, and a number of Aurora kinase inhibitors have been evaluated in the clinic. Herein we report the synthesis and their antiproliferation of 3,5-disubstituted-2-aminopyrazines as kinases inhibitors. Amongst, 4-((3-amino-6- (3,5-dimethylisoxazol-4-yl)pyrazin-2-yl)oxy)-N-(3-chlorophenyl) benzamide (12Aj) exhibited the strongest antiproliferative activities against U38, HeLa, HepG2 and LoVo cells with IC50 values were 11.5 ± 3.2, 1.34 ± 0.23, 7.30 ± 1.56 and 1.64 ± 0.48 μM, as well as inhibited Aurora A and B with the IC50 values were 90 and 152 nM, respectively. Molecular docking studies indicated that 12Aj appeared to form stable hydrogen bonds with either Aurora A or Aurora B. Furthermore, 12Aj arrested HeLa cell cycle in G2/M phase by regulating protein levels of cyclinB1 and cdc2. In addition, the bioinformatics prediction further revealed that 12Aj possessed good drug likeness using SwissADME. These results suggested that 12Aj was worthy of future development of potent anticancer agents as pan-Aurora kinases.

Synthesis of 4-(4-guanidinobenzoyloxy)benzamides and 1-(4-guanidinobenzoyloxy)benzoyloxy acetamides as trypsin inhibitors

Seventeen new compounds of 4-(4-guanidinobenzoyloxy)benzamides and 4-(4-guanidinobenzoyloxy)benzoyloxyacetamides were prepared and their inhibitory activities on trypsin, thrombin and porcine pancreatic elastase were measured. These compounds were found to be selective trypsin inhibitors with inhibiting activities from 0.44 to 43 μM.