85858-95-3

Basic information

• Product Name: 1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid
• Synonyms: 1,2,3,4-TETRAHYDRO-7-METHOXY-1-NAPHTHALENECARBOXYLIC ACID;7-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid
• CAS NO: 85858-95-3
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 85858-95-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 137.5-138.5 °C
• Boiling Point: 374.977 °C at 760 mmHg
• Flash Point: 147.008 °C
• Appearance: /
• Density: 1.195g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• PKA: 4.19±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid(85858-95-3)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid(85858-95-3)

Safety Data

• Hazardous Substances Data: 85858-95-3(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid is a chemical compound with the molecular formula C13H14O3. It is a derivative of naphthalene and carboxylic acid, containing a seven-membered ring structure with a methoxy group and a carboxylic acid group. 1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid is used in the pharmaceutical industry and has been studied for its potential anti-inflammatory and analgesic properties. It may also have applications in the treatment of neurodegenerative diseases. The exact mechanism of action and potential side effects of 1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid are still under investigation, and further research is needed to fully understand its medicinal potential.

InChI:InChI=1/C12H14O3/c1-15-9-6-5-8-3-2-4-10(12(13)14)11(8)7-9/h5-7,10H,2-4H2,1H3,(H,13,14)

Upstream product

• 91044-42-7 7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carbaldehyde 
• 218597-21-8 methyl 7-methoxy-3,4-dihydronaphthalene-1-carboxylate 
• 724707-85-1 trifluoromethanesulfonic acid 7-methoxy-3,4-dihydronaphthalen-1-yl ester 
• 62248-73-1 7-methoxy-1-cyano-1,2,3,4-tetrahydro-naphthalene 
• 140367-07-3 1-chloro-7-methoxy-1,2,3,4-tetrahydronaphthalene 
• 32820-10-3 7-methoxy-1,2,3,4-tetrahydro-1-naphthol 
• 182621-29-0 7-methoxy-1-(trimethylsilyloxy)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile 
• 6836-19-7 7-Methoxy-1-tetralone 
• 7677-24-9 trimethylsilyl cyanide 
• 218597-25-2 methyl 7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylate 
• 75910-81-5 α-cyano-3-methoxyphenylacetic acid ethyl ester 
• 107276-47-1 2-(3-Methoxy-phenyl)-2-cyan-glutarsaeure-diethylester 
• 79987-71-6 2-(3-methoxyphenyl)glutaric acid 
• 19924-43-7 3-methoxyphenylacetonitrile 

Downstream Products

• 7498-58-0 7-methoxynaphthalene-1-carboxylic acid 
• 405102-99-0 N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide 

Relevant articles and documents

Synthesis method of C5a receptor antagonist W-54011

The invention discloses a synthesis method of a C5a receptor antagonist W-54011. The synthesis method comprises the following steps: performing Wittig reaction, demethylation, enol interconversion, oxidation and the like to obtain 7-methoxy-1,2,3,4-tetrah

Asymmetric pericyclic cascade approach to spirocyclic oxindoles

The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.

NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF UGS

The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.