85862-77-7Relevant academic research and scientific papers
A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide
Babin, Victor,Sallustrau, Antoine,Loreau, Olivier,Caillé, Fabien,Goudet, Amélie,Cahuzac, Hélo?se,Del Vecchio, Antonio,Taran, Frédéric,Audisio, Davide
supporting information, p. 6680 - 6683 (2021/07/12)
Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach to label urea derivatives with all carbon isotopes, including14C and11C, based on a Staudinger aza-Wittig sequence. It provides access to all aliphatic/aromatic urea combinations.
Design, synthesis, and biological evaluation of new 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives
Vennam, Dinesh Kumar Reddy,Thatipamula, Ranjith Kumar,Haridasyam, Sharath Babu,Koppula, Shiva Kumar
, p. 630 - 637 (2018/08/17)
[Figure not available: see fulltext.] New 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives have been synthesized by a CuAAC reaction and their antibacterial and antifungal activity has been evaluated. Some of the derivatives showed
A reagent for safe and efficient diazo-transfer to primary amines: 2-azido-1,3-dimethylimidazolinium hexafluorophosphate
Kitamura, Mitsuru,Kato, So,Yano, Masakazu,Tashiro, Norifumi,Shiratake, Yuichiro,Sando, Mitsuyoshi,Okauchi, Tatsuo
, p. 4397 - 4406 (2014/06/23)
Organic azides were prepared from primary amines in high yields by a metal free diazo-transfer reaction using 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP), which is safe and stable crystalline. The choice of base was important in the diazo-transfer reaction. In general, 4-(N,N-dimethyl)aminopyridine (DMAP) was efficient, but a stronger base such as alkylamine or DBU was more appropriate for the reaction of nucleophilic primary amines. X-ray single crystal structural analysis and geometry optimization using density functional theory (B3LYP/6-31G**) were conducted to study the ADMP structure, and the diazo-transfer reaction mechanism was explained with the help of the results of these analyses. the Partner Organisations 2014.
Synthesis of calixarene-based bis(iminophosphoranes) and their use in Suzuki-Miyaura cross-coupling
Monnereau, Laure,Semeril, David,Matt, Dominique
body text, p. 2786 - 2791 (2012/07/01)
Calix[4]arene-derived bis(iminophosphoranes) have been synthesised and assessed in palladium-catalysed cross-couplings between phenylboronic acid and aryl bromides orchlorides. TOFs of up to 35100 mol(ArPh formed) mol(Pd) -1 h-1were
Direct synthesis of organic azides from primary amines with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate
Kitamura, Mitsuru,Yano, Masakazu,Tashiro, Norifumi,Miyagawa, Satoshi,Sando, Mitsuyoshi,Okauchi, Tatsuo
experimental part, p. 458 - 462 (2011/03/18)
Organic azides were prepared from primary amines in high yields by metal-free diazo transfer with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate, which is a stable, crystalline solid that is easy to handle. Organic azides were prepared from primary
Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2′- deoxyuridines and their antiviral evaluation
Montagu, Aurelien,Roy, Vincent,Balzarini, Jan,Snoeck, Robert,Andrei, Graciela,Agrofoglio, Luigi A.
experimental part, p. 778 - 786 (2011/03/20)
The synthesis and antiviral evaluation of a series of C5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)-nucleoside derivatives is described. The key steps of this synthesis are regioselective Huisgen's 1,3-dipolar cycloaddition, using either copper-catalyzed azide-alkyne cycloaddition (CuAAC) or ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) under microwave activation. Some compounds among the 5a-l series possess activity against herpes simplex viruses 1 and 2, varicella-zoster virus, human cytomegalovirus and vaccinia virus. Their cytostatic activities were determined against murine leukemia cells, human T-lymphocyte cells and cervix carcinoma cells. Compounds were also evaluated on a wide panel of RNA viruses, including Vesicular stomatitis virus, influenza viruses type A (H1N1 and H3N2) and B in MDCK cell cultures, parainfluenza-3 virus, reovirus-1, Sindbis virus and Punta Toro virus in Vero cell cultures and Vesicular stomatitis, Coxsackie B4 and respiratory syncytial virus, with no specific antiviral
Simple conversion of aromatic amines into azides
Liu, Qi,Tor, Yitzhak
, p. 2571 - 2572 (2007/10/03)
(Matrix presented) A straightforward and highly efficient synthesis of aromatic azides from the corresponding amines is accomplished using triflyl azide under mild conditions.
Mechanistic studies of pyrene-sensitized decomposition of p-butylphenyl azide: generation of nitrene radical anion through a sensitizer-mediated electron transfer from amines to the azide
Murata, Shigeru,Nakatsuji, Ryuichi,Tomioka, Hideo
, p. 793 - 800 (2007/10/02)
Pyrene-sensitized photolysis of p-butylphenyl azide (1) in acetonitrile containing diethylamine (DEA) gave a mixture of the 3H-azepine (2) and p-butylaniline (3).In order to reveal the mechanism of the formation of these photoproducts, the effects of the DEA or sensitizer concentration, solvents and various additives on the product distribution have been examined.Thus, it is proposed that the azepine 2 mainly originates from the singlet nitrene formed through the energy transfer from the excited pyrene to the azide 1, while the one-electron reduction of 1 with the pyrene radical anion produced through the electron transfer from DEA to singlet excited pyrene is involved in the formation of the aniline 3.
