858676-73-0

Basic information

• Product Name: 2-((2R,4R,6S)-6-(((4S,6S)-6-(((2R,4R,6S)-6-(((2R,4R,6R)-6-((E,3S,4S)-4-hydroxy-3,5-dimethylhex-1-enyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde
• Synonyms: 2-((2R,4R,6S)-6-(((4S,6S)-6-(((2R,4R,6S)-6-(((2R,4R,6R)-6-((E,3S,4S)-4-hydroxy-3,5-dimethylhex-1-enyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde
• CAS NO: 858676-73-0
• Molecular Weight: 813.041
• Mol File: 858676-73-0.mol

Chemical Properties

• CAS DataBase Reference: 2-((2R,4R,6S)-6-(((4S,6S)-6-(((2R,4R,6S)-6-(((2R,4R,6R)-6-((E,3S,4S)-4-hydroxy-3,5-dimethylhex-1-enyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2R,4R,6S)-6-(((4S,6S)-6-(((2R,4R,6S)-6-(((2R,4R,6R)-6-((E,3S,4S)-4-hydroxy-3,5-dimethylhex-1-enyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde(858676-73-0)
• EPA Substance Registry System: 2-((2R,4R,6S)-6-(((4S,6S)-6-(((2R,4R,6S)-6-(((2R,4R,6R)-6-((E,3S,4S)-4-hydroxy-3,5-dimethylhex-1-enyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde(858676-73-0)

Safety Data

• Hazardous Substances Data: 858676-73-0(Hazardous Substances Data)

Upstream product

• 1039456-22-8 (e,3S,4S)-6-((2R,4R,6R)-6-(((2R,4S,6R)-6-(((4S,6S)-6-(((2S,4S,6S)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)-2,4-dimethylhex-5-en-3-ol 
• 77-76-9 2,2-dimethoxy-propane 
• 858676-92-3 benzyl-(2-{6-[6-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2-phenyl-[1,3]dioxan-4-yl}-vinyl)-dimethyl-silane 
• 858676-94-5 {6-[6-(6-{6-[4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-2-phenyl-[1,3]dioxan-4-yl}-acetaldehyde 

Downstream Products

• 154396-73-3 RK-397 
• 858676-96-7 C₅₉H₇₂O₁₀ 

Relevant articles and documents

Formal total synthesis of RK-397 via an asymmetric hydration and iterative allylation strategy

(Chemical Equation Presented) A formal total synthesis of the oxopentaene macrolide antibiotic RK-397 has been achieved. Nine stereocenters were established by a combination of allylation and our asymmetric hydration reactions and a 1,5-anti-selective ald

Total synthesis of RK-397

An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly convergent synthesis. The synthesis highlights stereoselective vinylogous aldol addition using a chiral bisphosphoramide as well as a sequential palladium-catalyzed cross-coupling reaction for the preparation of key fragments. Copyright