85868-66-2Relevant academic research and scientific papers
Synthesis and Structure Activity Relationship in 1-(Substituted aminophenoxy)-3-1-(N4-arylpiperazinyl)>propanes
Agarwal, Shiv K.,Saxena, Anil K.,Jain, Padam C.,Anand, Nitya
, p. 914 - 918 (2007/10/02)
1-(Aminophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (1-8) have been prepared by the catalytic hydrogenation of 1-(nitrophenoxy)-3-1-(N4-arylpiperazinyl)>propanes.The reaction of aminophenoxypiperazinylpropanes (1-8) with acetic anhydride gives the corresponding 1-(acetamidophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (9-15) and with methanesulphonyl chloride the corresponding 1-(methanesulfonamidophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (16-19) are obtained.The amino compounds (3 and 4) on treatment with lactim thioethers and isocyanates/isothiocanates afford the corresponding 1-- (20-30) and 1-(ureido/thioureidophenoxy)-3-1-(N44-arylpiperazinyl)>propanes (31-37).Some of these compunds show potent CNS depressant, hypotensive, α-adrenoceptor blocking, antiinflammatory and diuretic activities.Among these compounds 1-(4-aminophenoxy)-3-1-(N4-(2-methoxyphenyl)piperazinyl)>propane (4) is found to be potent neuroleptic.
