85868-68-4

Basic information

• Product Name: N-{4-[3-(4-phenylpiperazin-1-yl)propoxy]phenyl}-4,5-dihydro-3H-1-benzazepin-2-amine
• CAS NO: 85868-68-4
• Molecular Formula: C₂₉H₃₄N₄O
• Molecular Weight: 454.6065
• Mol File: 85868-68-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 665.2°C at 760 mmHg
• Flash Point: 356.1°C
• Density: 1.15g/cm³
• Vapor Pressure: 1.45E-17mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: N-{4-[3-(4-phenylpiperazin-1-yl)propoxy]phenyl}-4,5-dihydro-3H-1-benzazepin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-[3-(4-phenylpiperazin-1-yl)propoxy]phenyl}-4,5-dihydro-3H-1-benzazepin-2-amine(85868-68-4)
• EPA Substance Registry System: N-{4-[3-(4-phenylpiperazin-1-yl)propoxy]phenyl}-4,5-dihydro-3H-1-benzazepin-2-amine(85868-68-4)

Safety Data

• Hazardous Substances Data: 85868-68-4(Hazardous Substances Data)

Upstream product

• 84344-45-6 1-(4-nitrophenoxy)-3-1-(N⁴-phenylpiperazinyl)>propane 
• 85868-46-8 1-<4-aminophenoxy>-3-1-(N⁴-phenylpiperazinyl)>propane 
• 30675-01-5 2-Methylthio-4,5-dihydro-3H-benzazepin 

Relevant articles and documents

Synthesis and Structure Activity Relationship in 1-(Substituted aminophenoxy)-3-1-(N4-arylpiperazinyl)>propanes

1-(Aminophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (1-8) have been prepared by the catalytic hydrogenation of 1-(nitrophenoxy)-3-1-(N4-arylpiperazinyl)>propanes.The reaction of aminophenoxypiperazinylpropanes (1-8) with acetic anhydride gives the corresponding 1-(acetamidophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (9-15) and with methanesulphonyl chloride the corresponding 1-(methanesulfonamidophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (16-19) are obtained.The amino compounds (3 and 4) on treatment with lactim thioethers and isocyanates/isothiocanates afford the corresponding 1-- (20-30) and 1-(ureido/thioureidophenoxy)-3-1-(N44-arylpiperazinyl)>propanes (31-37).Some of these compunds show potent CNS depressant, hypotensive, α-adrenoceptor blocking, antiinflammatory and diuretic activities.Among these compounds 1-(4-aminophenoxy)-3-1-(N4-(2-methoxyphenyl)piperazinyl)>propane (4) is found to be potent neuroleptic.