85888-50-2Relevant academic research and scientific papers
Isolation and Characterization of the Radiation-Induced Degradation Products of 2'-Deoxyguanosine in Oxygen-Free Aqueous Solutions
Berger, Maurice,Cadet, Jean
, p. 1519 - 1531 (2007/10/02)
The bulk of the radiation-induced degradation products of 2'-deoxyguanosine on oxygen-free aqueous solution have been separated by high performance liquid chromatography and characterized by various spectroscopic techniques including fast atom bombardment mass spectrometry, 1H NMR and circular dichroism.The two main decomposition products result from the opening of the imidazole ring and further rearrangement of the sugar moiety.In addition, the formation of six other nucleosides was shown to involve sugar radicals with subsequent epimerization, rearrangement or cyclization reactions. - Keywords: 2'-Deoxyguanosine, Gamma Irradiation, Hydroxyl Radicals, 1H NMR Spectra, Modified Nucleosides
