858941-29-4Relevant academic research and scientific papers
Conformational constraint as a means for understanding RNA-aminoglycoside specificity
Blount, Kenneth F.,Zhao, Fang,Hermann, Thomas,Tor, Yitzhak
, p. 9818 - 9829 (2007/10/03)
The lack of high RNA target selectivity displayed by aminoglycoside antibiotics results from both their electrostatically driven binding mode and their conformational adaptability. The inherent flexibility around their glycosidic bonds allows them to easi
