85899-55-4

Basic information

• Product Name: 8,5'-cyclo-2',5'-dideoxyguanosine
• CAS NO: 85899-55-4
• Molecular Weight: 249.229
• Mol File: 85899-55-4.mol

Chemical Properties

• CAS DataBase Reference: 8,5'-cyclo-2',5'-dideoxyguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 8,5'-cyclo-2',5'-dideoxyguanosine(85899-55-4)
• EPA Substance Registry System: 8,5'-cyclo-2',5'-dideoxyguanosine(85899-55-4)

Safety Data

• Hazardous Substances Data: 85899-55-4(Hazardous Substances Data)

Upstream product

• 961-07-9 2'-Deoxyguanosine 
• 902-04-5 2'-deoxyguanosine 5'-monophosphate 

Relevant articles and documents

RADIATION CHEMISTRY OF DNA COMPONENTS. FORMATION OF THE 8,5'-CYCLO-2',5'-DIDEOXYGUANOSINE BY GAMMA IRRADIATION OF DEAERATED AQUEOUS SOLUTIONS OF 2'-DEOXYGUANOSINE AND ITS 5'-MONOPHOSPHATE ESTER

8,5'-cyclo-2',5'-dideoxyguanosine was shown to be produced by gamma irradiation of deaerated aqueous solutions of 2'-deoxyguanosine and 2'-deoxyguanosine-5'-monophosphate, subsequent to initial hydrogen abstraction at the osidic carbon C(4').Structure assignment was made on the basis of UV, 1H and 13C NMR, mass spectrometry analyses, and confirmed by an independent synthesis.

Isolation and Characterization of the Radiation-Induced Degradation Products of 2'-Deoxyguanosine in Oxygen-Free Aqueous Solutions

The bulk of the radiation-induced degradation products of 2'-deoxyguanosine on oxygen-free aqueous solution have been separated by high performance liquid chromatography and characterized by various spectroscopic techniques including fast atom bombardment mass spectrometry, 1H NMR and circular dichroism.The two main decomposition products result from the opening of the imidazole ring and further rearrangement of the sugar moiety.In addition, the formation of six other nucleosides was shown to involve sugar radicals with subsequent epimerization, rearrangement or cyclization reactions. - Keywords: 2'-Deoxyguanosine, Gamma Irradiation, Hydroxyl Radicals, 1H NMR Spectra, Modified Nucleosides