85908-45-8Relevant academic research and scientific papers
Investigation of the reaction of α-thioamides, α-esters and α-nitriles with N-halosuccinimides
Kissane, Marie,Murphy, Maureen,Lynch, Denis,Ford, Alan,Maguire, Anita R.
, p. 7639 - 7649 (2008/12/20)
Investigation of the reaction of α-thioamides, α-esters and α-nitriles with NBS and NCS is described. The?scope of this stereoselective oxidative transformation to the β-haloacrylamides, β-acrylates and β-acrylonitriles has been determined. A mechanistic
Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent
Camps, Pelayo,Gomez, Tania,Munoz-Torrero, Diego,Rull, Jordi,Sanchez, Laura,Boschi, Francesca,Comes-Franchini, Mauro,Ricci, Alfredo,Calvet, Teresa,Font-Bardia, Merce,De Clercq, Erik,Naesens, Lieve
, p. 6657 - 6665 (2008/12/23)
(Chemical Equation Presented) A series of novel N,O-psiconucleosides has been prepared in both enantiomeric forms by resolution of an advanced racemic synthetic intermediate using (R)-N-phenylpantolactam as a chiral resolution agent. The absolute configur
Inhibitors of glycogen synthase kinase 3
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, (2008/06/13)
New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
CHIMIE des FRAGRANCES. PARTIE I : NOUVELLE STRATEGIE de SYNTHESE de α-(2-OXOCYCLOHEXYL)-ACRYLATES de METHYLE
Leyendecker, Francois,Comte, Marie-Therese
, p. 1413 - 1422 (2007/10/02)
Highly stereoselective tandem 1,4-addition-functionalisation reactions have been performed on various cyclohexenones using methyl α-sulphinylacrylate as an efficient enolate trapping reagent.
NEW ACETYLENIC MICHAEL RECEPTOR EQUIVALENTS. PART I : SYNTHESIS OF α-SULFENYL - AND α-SULFINYL ACRYLIC DERIVATIVES.
Leyendecker, Francois,Comte, Marie-Therese
, p. 5031 - 5034 (2007/10/02)
The synthesis of α-thioarylated β-unsubstituted acrilic derivatives is reported.
