859179-67-2Relevant academic research and scientific papers
Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library
Zhang, Qiong,Liu, Yi,Gao, Feng,Ding, Qiang,Cho, Charles,Hur, Wooyoung,Jin, Yunho,Uno, Tetsuo,Joazeiro, Claudio A. P.,Gray, Nathanael
, p. 2182 - 2183 (2007/10/03)
The epidermal growth factor receptor (EGFR) tyrosine kinase was one of the first receptor tyrosine kinases to be targeted for drug development by the pharmaceutical industry due to its ubiquitous overexpression in a variety of tumors. Despite the validati
