859205-88-2

Basic information

• Product Name: 5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine
• Synonyms: 5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine;5-Methyl-4-(Methylthio)py...;5-Methyl-4-(Methylthio)pyrrolo[2,1-f][1,2,4]triazine;5-methyl-4-(methylsulfanyl)pyrrolo[2,1-f][1,2,4]triazine;5-Methyl-4-(methylthio)
• CAS NO: 859205-88-2
• Molecular Formula: C₈H₉N₃S
• Molecular Weight: 179.246
• Product Categories: CHIRAL CHEMICALS
• Mol File: 859205-88-2.mol

Chemical Properties

• Appearance: /
• Density: 1.3 g/cm³
• Refractive Index: 1.679
• CAS DataBase Reference: 5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine(859205-88-2)
• EPA Substance Registry System: 5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine(859205-88-2)

Safety Data

• Hazardous Substances Data: 859205-88-2(Hazardous Substances Data)

Usage

Uses

Given the limited information available on 5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine, potential uses can be hypothesized based on its chemical structure:
Used in Pharmaceutical Industry:
5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine could be utilized as a pharmaceutical agent for its potential bioactivity. The presence of heterocyclic rings and functional groups may endow it with specific pharmacological properties, which could be harnessed for the development of new drugs.
Used in Agrochemical Industry:
In agrochemicals, 5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine might serve as a precursor or active ingredient in the synthesis of pesticides or herbicides. Its chemical structure could allow it to interact with biological targets in pests or weeds, providing a new method for crop protection.
Used in Materials Science:
5-methyl-4-(methylthio)pyrrolo[1,2-f][1,2,4]triazine could be explored for its potential use in the development of new materials. Its heterocyclic nature might contribute to the formation of polymers or other materials with unique electronic, optical, or mechanical properties.

InChI:InChI=1/C8H9N3S/c1-6-3-4-11-7(6)8(12-2)9-5-10-11/h3-5H,1-2H3

Upstream product

• 529508-54-1 C₇H₇N₃O 
• 1392140-56-5 ethyl 1-amino-3-methyl-1H-pyrrole-2-carboxylate 
• 3284-47-7 ethyl 3-methyl-1H-pyrrole-2-carboxylate 
• 529508-56-3 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 859205-93-9 (S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF

The present invention relates to a group of pyrrolo[2, 1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases

Novel C-5 substituted pyrrolotriazines were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. The lead compound exhibited promising oral efficacy in both EGFR and HER2 driven human tumor xenograft models. It is hypothesized that its C-5

PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of formula (I); and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Di-substituted pyrrolotrizine compounds

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.