859216-40-3

Upstream product

• 474915-86-1 (3S,4S)-5-(Z)-benzylidene-3-hydroxy-3-propionyl-4-triisopropylsiloxypyrrolidin-2-one 

Downstream Products

• 859216-46-9 (5S,8R,9R)-((1S,2R)-(Z)-1,2-epoxy-hex-3-enyl)-8-(hydroxy-phenyl-methyl)-8-methoxy-3-methyl-9-trimethylsilyloxy-1-oxa-7-azaspirop[4.4]non-2-ene-4,6-dione 
• 860020-01-5 (5S,8S,9R)-8-benzoyl-2-((1S,2R)-(Z)-1,2-epoxy-hex-3-enyl)-8-methoxy-3-methyl-9-trimethylsilyloxy-1-oxa-7-azaspirop[4.4]non-2-ene-4,6-dione 
• 859216-45-8 (5S,9S)-8-(Z)-benzylidene-2-((1S,2R)-(Z)-1,2-epoxy-hex-3-enyl)-3-methyl-9-trimethylsilyloxy-1-oxa-7-azaspirop[4.4]non-2-ene-4,6-dione 
• 127941-81-5 (+)-synerazol 
• 859216-42-5 (3S,4S)-5-(Z)-benzylidene-3-((4R,5R)-(Z)-4,5-epoxy-3-hydroxy-2-methylnon-6-enoyl)-hydroxy-4-trimethylsilanyloxy-pyrrolidin-2-one 

Relevant academic research and scientific papers

First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry

By synthesizing two possible diastereomers, the first asymmetric total synthesis of synerazol, an antifungal antibiotic, has been accomplished, allowing determination of its absolute stereochemistry. A more practical second generation route was also estab