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SYNTHESIS OF 2-t-BUTYL-5-HYDROXYPYRIMIDINE VIA HYDROLYSIS OF 2-t-BUTYL-5-HALOPYRIMIDINES
Pews, Richard Garth
, p. 109 - 114 (2007/10/02)
The hydrolysis of 2-t-butyl-5-halopyrimidine (halogen = bromine or chlorine) with sodium methoxide in methanol yields 2-t-butyl-5-hydroxypyrimidine.The side reaction product, 2-t-butylpyrimidine, is substantially reduced, especially in the case of the bromo derivative, with catalytic amounts of elemental sulfur.
