859307-45-2

Basic information

• Product Name: ethyl N-(3-cyanopropyl)-N-phenylglycinate
• Synonyms: ethyl N-(3-cyanopropyl)-N-phenylglycinate
• CAS NO: 859307-45-2
• Molecular Weight: 246.309
• Mol File: 859307-45-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl N-(3-cyanopropyl)-N-phenylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-(3-cyanopropyl)-N-phenylglycinate(859307-45-2)
• EPA Substance Registry System: ethyl N-(3-cyanopropyl)-N-phenylglycinate(859307-45-2)

Safety Data

• Hazardous Substances Data: 859307-45-2(Hazardous Substances Data)

Upstream product

• 2216-92-4 N-phenylglycine ethyl ester 
• 62-53-3 aniline 
• 73747-25-8 4-(phenylamino)butyronitrile 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 148494-90-0 (2S)-phenyl-3-piperidone 
• 33342-99-3 (+/-)-2-methyl-1-phenylpyrrolidine 
• 858815-05-1 4-(N-ethoxycarbonylmethyl-anilino)-butyric acid ethyl ester 

Relevant articles and documents

Copper-Catalyzed Cyanoalkylation of Amines via C-C Bond Cleavage: An Approach for C(sp3)-N Bond Formations

The efficient copper-catalyzed cyanoalkylation of amines via C-C bond cleavage has been demonstrated. Distinctive features of this procedure involves mild conditions, broad range of nitrogen nucleophiles, high selectivity, and good functional group tolerance, thus providing a useful approach for the C(sp3)-N bond formations. Most importantly, this protocol is applicable to the late-stage functionalization of natural products, amino acid esters, and drugs. Mechanistic studies suggest that a radical intermediate was involved in this transformation.