85952-73-4

Basic information

• Product Name: N-(4-Fluorobenzyl)cyclopentylaMine, 97%
• Synonyms: N-(4-Fluorobenzyl)cyclopentylaMine, 97%;N-Cyclopentyl-4-fluoro-benzylaMine
• CAS NO: 85952-73-4
• Molecular Formula: C₁₂H₁₆FN
• Molecular Weight: 193.2605432
• Mol File: 85952-73-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Fluorobenzyl)cyclopentylaMine, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Fluorobenzyl)cyclopentylaMine, 97%(85952-73-4)
• EPA Substance Registry System: N-(4-Fluorobenzyl)cyclopentylaMine, 97%(85952-73-4)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 85952-73-4(Hazardous Substances Data)

Usage

Uses

Cyclopentyl-(4-fluoro-benzyl)-amine is a useful for screening and treating prostrate cancer.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 1003-03-8 Cyclopentamine 

Downstream Products

• 691007-99-5 4-cyano-N-cyclopentyl-5-[(2-ethylbutanoyl)amino]-N-(4-fluorobenzyl)-3-methylthiophene-2-carboxamide 
• 85952-41-6 N-4-fluorobenzyl-N-cyclopentyl-N'-phenylthiourea 

Relevant articles and documents

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide???Heteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket

We report an extensive “heteroarene scan” of triazine nitrile ligands of the cysteine protease human cathepsin L (hCatL) to investigate π-stacking on the peptide amide bond Gly67–Gly68 at the entrance of the S3 pocket. This heteroarene???peptide bond stacking was supported by a co-crystal structure of an imidazopyridine ligand with hCatL. Inhibitory constants (Ki) are strongly influenced by the diverse nature of the heterocycles and specific interactions with the local environment of the S3 pocket. Binding affinities vary by three orders of magnitude. All heteroaromatic ligands feature enhanced binding by comparison with hydrocarbon analogues. Predicted energetic contributions from the orientation of the local dipole moments of heteroarene and peptide bond could not be confirmed. Binding of benzothienyl (Ki=4 nm) and benzothiazolyl (Ki=17 nm) ligands was enhanced by intermolecular C?S???O=C interactions (chalcogen bonding) with the backbone C=O of Asn66 in the S3 pocket. The ligands were also tested for the related enzyme rhodesain.

MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

Combating fungi with novel (thio-)ureas, and novel intermediates therefor

(Thio)-ureas of the formula STR1 in which R1 is an optionally alkyl-substituted cycloalkyl radical or a halogenoalkyl radical, R2 is an alkyl or cycloalkyl radical or an optionally substituted aryl radical, Ar is an optionally substi