85969-93-3Relevant academic research and scientific papers
Synthesis of maculalactone A and derivatives for environmental fate tracking studies
Bader, Samuel L.,Luescher, Michael U.,Gademann, Karl
, p. 199 - 206 (2014)
Maculalactone A (1) constitutes a promising antifouling agent, inhibiting the formation of biofilms in marine and freshwater systems. In this study, we developed a new route, based on a late-stage formation of the butenolide core, leading to the total synthesis of maculalactone A (three steps, overall yield of 45%) and delivering material on a gram scale. In addition, analogues of the title compound were assayed concerning their biological activity, utilizing Artemia franciscana and Thamnocephalus platyurus. The most active analogue was functionalized with a rhodamine B fluorophore and was utilized in an in vivo staining experiment in Artemia salina. Two different tissues were found to accumulate this maculalactone A derivative. This journal is
PREPARATION OF α-BROMOESTERS VIA THE HALF ESTERS OF MALONIC ACIDS A NOVEL METHOD FOR RAPID DECARBOXYLATION UNDER MILD CONDITIONS
Goel, O. P.,Krolls, U.
, p. 163 - 166 (2007/10/02)
α-Bromomalonic acid half esters were prepared in high yield and found to be rapidly decarboxylated to α-bromoesters under mild conditions using lithium carbonate in refluxing tetrahydrofuran.
