85979-59-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-(4-fluoro-phenyl)-pyrimidine is used as a chemical intermediate for the production of pharmaceuticals. Its unique structure and properties make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-Chloro-4-(4-fluoro-phenyl)-pyrimidine is used as a building block for the synthesis of agrochemicals. Its potential applications in this industry include the development of new pesticides, herbicides, or other agrochemicals with improved efficacy and selectivity.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 865073-91-2 4-(4-fluorophenyl)-2-phenylpyrimidine 
• 1603830-28-9 3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole 
• 1603830-22-3 3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-1-methyl-1H-pyrrolo[3,2-b]quinoline 
• 1580440-41-0 1-(4-(4-fluorophenyl)pyrimidin-2-yl)-4-hydroxypiperidine-4-carboxylic acid 
• 1580437-71-3 1-azabicyclo[3.2.2]nonan-4-yl 1-(4-(4-fluorophenyl)pyrimidin-2-yl)piperidine-4-carboxylate 
• 1580437-01-9 1-(4-(4-fluorophenyl)pyrimidin-2-yl)-N-(quinuclidin-3-yl)piperidine-4-carboxamide 
• 1580440-34-1 1-[4-(4-fluorophenyl)pyrimidin-2-yl]piperidine-4-carboxylic acid 
• 1580440-33-0 ethyl 1-[4-(4-fluorophenyl)pyrimidin-2-yl]piperidine-4-carboxylate 
• 1401162-81-9 4-(4-fluorophenyl)pyrimidine-2-carbaldehyde 
• 1401162-80-8 methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate 

Relevant academic research and scientific papers

Radiosensitizing effect of novel phenylpyrimidine derivatives on human lung cancer cells via cell cycle perturbation

Radiotherapy is one of the most common treatments for cancer, but radioresistance and injury to normal tissue are considered major obstacles to successful radiotherapy. Thus, there is an urgent need to develop radiosensitizers to improve the therapeutic o

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention discloses compounds according to Formula I: Wherein R 1a, R 1b, R 2, R 4, R5, R 6, R 7, R 8, W, X, Y, Z, Cy, and the subscript a are as defined h

One-pot double Suzuki couplings of dichloropyrimidines

An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and requiring correspondingly lower temperatures than the use of polar aprotic solvents. Georg Thieme Verlag Stuttgart.

PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS

The invention relates to pyrimidin-2-one compounds of general formula (I), in addition to the derivatives and tautomers of (I) and the physiologically acceptable salts of said compounds. In said formula: A represents linear or branched C3-C6 alkene, which can have a double bond or triple bond and/or a group Z, which is not adjacent to the nitrogen atom of the pyrimidinone ring and is selected from O, S, C(O), NR3, C(O)NR3, NR3C(O), OC(O) and C(O)O; B represents a group of formula (II), in which X stands for CH2 or N and Y stands for CH2 or CH2CH2, or X-Y can also jointly represent C=CH, C=CH-CH2 or CH-CH=CH; R1 and R 2 are defined as cited in the description and the claims; and Ar represents an optionally substituted aromatic group. The invention also relates to a pharmaceutical agent, containing at least one compound (I) and the tautomers, derivatives and/or acid addition salts of said compound, optionally together with physiologically acceptable carriers and/or auxiliary agents. The invention also relates to the use of compounds of formula (I), and their tautomers, derivatives and pharmacologically acceptable acid addition salts for producing a pharmaceutical agent for treating diseases, which respond to the influence of dopamine D3 receptor ligands.

Aryl-substituted pyrimidines as insecticidal and acaricidal agents

There are provided compositions and methods comprising compounds of formula I: STR1 wherein R1, A, B, X, Y and Z have the meaning given in claim 1, for the control of insect and acarid pests.