859831-63-3Relevant academic research and scientific papers
Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARγ activators
Kumar, Rakesh,Mittal, Amit,Ramachandran, Uma
, p. 4613 - 4618 (2008/03/11)
The design and synthesis of novel series of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (pyrimidone) derivatives that are high affinity ligands for peroxisome proliferators activated receptor γ have been reported as a potential substitu
Design, synthesis and evaluation of carbazole derivatives as PPARα/γ dual agonists and antioxidants
Kumar, Rakesh,Ramachandran, Uma,Srinivasan, Krishnamoorthy,Ramarao, Poduri,Raichur, Suryaprakash,Chakrabarti, Ranjan
, p. 4279 - 4290 (2007/10/03)
A series of hydroxycarbazole derivatives were synthesized and evaluated for PPARα/γ dual agonist as well as antioxidant activities. While most compounds showed good antioxidant activity, some compounds were identified as potential PPARα/γ dual agonists as well. Compounds 10a and 16 were found to be active in animal studies.
