859845-19-5

Basic information

• Product Name: {2-[(2R,3S,4S,6R)-6-((E)-(1R,2S)-1,2-Bis-benzyloxy-4-iodo-but-3-enyl)-4-methoxymethoxy-3-methyl-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane
• Synonyms: {2-[(2R,3S,4S,6R)-6-((E)-(1R,2S)-1,2-Bis-benzyloxy-4-iodo-but-3-enyl)-4-methoxymethoxy-3-methyl-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane
• CAS NO: 859845-19-5
• Molecular Weight: 834.907
• Mol File: 859845-19-5.mol

Chemical Properties

• CAS DataBase Reference: {2-[(2R,3S,4S,6R)-6-((E)-(1R,2S)-1,2-Bis-benzyloxy-4-iodo-but-3-enyl)-4-methoxymethoxy-3-methyl-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[(2R,3S,4S,6R)-6-((E)-(1R,2S)-1,2-Bis-benzyloxy-4-iodo-but-3-enyl)-4-methoxymethoxy-3-methyl-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane(859845-19-5)
• EPA Substance Registry System: {2-[(2R,3S,4S,6R)-6-((E)-(1R,2S)-1,2-Bis-benzyloxy-4-iodo-but-3-enyl)-4-methoxymethoxy-3-methyl-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane(859845-19-5)

Safety Data

• Hazardous Substances Data: 859845-19-5(Hazardous Substances Data)

Upstream product

• 380909-82-0 (S)-4-Benzyl-3-[(2S,3R)-5-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-pentanoyl]-oxazolidin-2-one 
• 859844-87-4 {2-[(2R,3S,4S,6R)-6-((1R,2S)-1,2-Bis-benzyloxy-but-3-ynyl)-4-methoxymethoxy-3-methyl-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane 
• 859844-81-8 (3S,4S,7S,8R,9R)-3,4-Bis-benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-8-methyl-9-triethylsilanyloxy-undec-1-yn-5-one 
• 859845-15-1 (2R,3R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-3-triethylsilanyloxy-pentan-1-ol 
• 859844-79-4 (2S,3R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-3-triethylsilanyloxy-pentanal 
• 859845-13-9 (3R,4S)-3,4-Bis-benzyloxy-hex-5-yn-2-ol 
• 859844-76-1 (3S,4S)-3,4-Bis-benzyloxy-hex-5-yn-2-one 
• 859845-11-7 (2S,3S)-2,3-Bis-benzyloxy-pent-4-ynal 
• 859844-83-0 (2R,4S,5R,6R)-2-((1S,2S)-1,2-Bis-benzyloxy-but-3-ynyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol 
• 859844-85-2 (2R,4R,5R,6R)-2-((1S,2S)-1,2-Bis-benzyloxy-but-3-ynyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-ol 
• 859845-18-4 (2R,5S,6R)-2-((1S,2S)-1,2-Bis-benzyloxy-but-3-ynyl)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methoxy-5-methyl-tetrahydro-pyran-4-one 
• 859845-17-3 (2R,3R,4S,6R)-6-((1R,2S)-1,2-Bis-benzyloxy-but-3-ynyl)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-methyl-tetrahydro-pyran-4-ol 
• 859845-14-0 (S)-4-Benzyl-3-[(2S,3R)-5-(tert-butyl-diphenyl-silanyloxy)-2-methyl-3-triethylsilanyloxy-pentanoyl]-oxazolidin-2-one 

Downstream Products

• 859845-20-8 (E)-(1S,2S)-7-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4S,5S,6R)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methoxymethoxy-5-methyl-tetrahydro-pyran-2-yl}-hept-3-ene-1,2-diol 
• 859845-22-0 5-[2-((2R,3S,4S,6R)-6-{(4R,5S)-5-[(E)-5-(tert-Butyl-dimethyl-silanyloxy)-pent-1-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-4-methoxymethoxy-3-methyl-tetrahydro-pyran-2-yl)-ethylsulfanyl]-1-phenyl-1H-tetrazole 
• 859844-89-6 (2R,3S,4S,6R)-6-[(E)-(1R,2S)-1,2-Bis-benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-hept-3-enyl]-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methoxymethoxy-3-methyl-tetrahydro-pyran 

Relevant articles and documents

(+)-Sorangicin A synthetic studies. Construction of the C(1-15) and C(16-29) subtargets

(Chemical Equation Presented) Effective stereocontrolled syntheses of subtargets (-)-2 and (-)-4, comprising respectively the C(16-29) and C(1-15) tetrahydropyran and dihydropyran moieties of the potent antibiotic (+)-sorangicin A (1), have been achieved. The cornerstone for the synthesis of (-)-2 involved an aldol tactic exploiting 1,4-induction, followed in turn by an acid-mediated cyclization/ketalization and hydrosilane reduction promoted by TMSOTf, while construction of (-)-4 entailed a stereoselective conjugate addition/α-oxygenation sequence.